RTOG 0211 A PHASE I/II STUDY OF AN ORAL EPIDERMAL GROWTH
FACTOR RECEPTOR TYROSINE KINASE INHIBITOR (EGFR-TKI), ZD 1839 (IRESSA), [NSC#
715055] WITH RADIATION THERAPY IN GLIOBLASTOMA MULTIFORME
Radiotherapy must begin within
4 weeks after surgery. One treatment of 2.0 Gy will be given daily, 5 days per
week, (over six weeks) for a total of 60.0 Gy. All portals shall be treated during
each treatment session. Doses are specified as the target dose, which shall be to the
center of the target volume.
Localization, Simulation, and Immobilization
The patient shall be treated in the supine or other appropriate position for the location
of the lesion. A head-holding device that is transparent to x-rays must ensure adequate
immobilization during therapy and ensure reproducibility. The target volume for both the
initial volume and the conedown volume shall be based on the preoperative CT/MRI.
The initial target volume shall include the contrast-enhancing lesion and surrounding
edema (if it exists) demonstrated on CT/MRI plus a 2.0 centimeter margin. If no
surrounding edema is present, the initial target volume should include the
contrast-enhancing lesion plus a 2.5 centimeter margin.
This initial target volume will be treated to 46.0 Gy in 23 fractions, 2.0 Gy per
fraction. After 46 Gy, the conedown target volume should include the contrast-enhancing
lesion (without edema) on the pre-surgery CT/MRI scan plus a 2.5 centimeter margin.
The conedown volume will be treated to an additional 14.0 Gy in 7 fractions, 2.0 Gy per
fraction. This will bring the total target dose to 60 Gy in 30 fractions.
Dose Limitations to Critical Structures
The lens and cervical spine must be shielded from the direct beam at all times. When
possible to do without shielding gross tumor, attempts should be made to limit the dose to
the optic chiasm to 60 Gy, the retina of at least one eye (but preferably both) to 50 Gy,
and the brain stem to 60 Gy. When the optic chiasm must be included in the full dose,
there may be a finite unknown risk of developing blindness. |